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CNN —The weight loss drug Wegovy was shown to reduce the risk of heart attack, stroke or heart disease-related death by 20% in a major clinical trial in people with cardiovascular disease, the first to show a weight loss drug alone can have such protective effects. It called the five-year trial “Select.”The finding of a 20% reduction in heart risk is higher than many experts had anticipated. A similar trial for the type 2 diabetes drug Ozempic, which uses the same ingredient, semaglutide, previously showed it could reduce cardiovascular risk by 26% — but no trial had yet shown a risk reduction in people without diabetes. It said it will present detailed results from the trial at a scientific conference later this year. It’s awaiting US Food and Drug Administration approval for weight loss as well.
Persons: Wegovy, 2.4mg, , Martin Holst Lange, Novo, Dr, Willa Hsueh, Jena Shaw Tronieri, Sanjay Gupta, Fuller, Steven Nissen, Eli Lilly, It’s, ” Nissen, he’d Organizations: CNN, Novo Nordisk, Diabetes, Metabolism Research, Wexner, The Ohio State University, Clinical Services, Center, Perelman School of Medicine, University of Pennsylvania, Nordisk, CNN Health, Cleveland, Food and Drug
Scientists have previously revived ancient bacteria and prehistoric viruses that had been trapped. Scientists have a long record of resurrecting prehistoric viruses and ancient bacteria frozen in ice. However, as the climate crisis is melting ancient ice sheets worldwide, experts are growing concerned that prehistoric viruses could pose a risk to humanity. Other research has found 28 prehistoric viruses dating back 15,000 years in frozen ice cores. It's very difficult to keep samples pristine when extracting ancient ice, and even more difficult to conclusively date the ice.
Persons: Lonnie Thompson, Jean, Michel Claverie, it's, Birgitta Evengård, It's, hadn't Organizations: Service, Privacy, The Ohio State University, Byrd, Climate Research, Umea University, CNN Locations: Yao, Tibetan, French, Antarctica, Russia
A new study finds that an Ivy League degree doesn't meaningfully increase a graduate's future income compared to attending a good state school. Americans are debating the merits of affirmative action and legacy admissions at Ivy League schools. While attending an Ivy League school only increased students' future income by 3% on average, the researchers found that it boosted any one student's chances of reaching the top 1% in income at age 33 by 59%. So while attending an Ivy didn't meaningfully boost students' odds of making more money on average, it did boost their odds of getting super-duper rich. Age 33 income levels were projected using a student's current income and data on their employers and graduate schools.
Persons: , Alan Kruger, Ivy, Ivy — Organizations: Ivy League, Service, Ivy League university —, Opportunity, Harvard, Princeton, Ivy, ACT, Ohio State University, UC Berkeley, UCLA, University of Florida, University of Georgia, University of Michigan, University of North, University of Texas, University of Virginia Locations: Wall, Silicon, University of North Carolina
But Midwestern cities are also facing a crisis of their own — struggling to attract workers, residents, and visitors to their downtowns. Nine of the 13 Midwestern cities tracked in the study were in the bottom half of the rankings. In the early part of the 20th century, Midwestern cities boomed — attracting workers and families seeking out manufacturing jobs and education. Many Midwestern cities relied on a single industry or even a single company to buttress its economy. "If office workers are coming downtown less, but college students are willing to come downtown more, what about literally putting a college in your downtown?"
Persons: COVID, Michael Hicks, Jacob Frey, Salesforce, Karen Chapple, Hicks, Michael Siluk, Amanda Weinstein, Weinstein, weren't, it's, Tracy Hadden Loh, Hadden Loh, It's, they've, you've, Chapple, Edwin Remsberg, downtowns, I've, , Columbus, Keyvan Esfarjani, Eliza Relman Organizations: metros —, metros, Ball State University, University of Toronto, St, of Cities, Midwest, University of Akron, Brookings Institution, Institution, Arizona State University, Cleveland, Housing, While Ohio, Ohio State University's, Intel Locations: San Francisco, Seattle, Indiana, Midwest, Louis, Indianapolis, Minneapolis, Cleveland, Kansas City , Missouri, Detroit, Akron, leafier, downtowns, Lake Erie, Burke, Downtown, Kansas, Chicago, Columbus, While, Ohio
Washington CNN —Former President Donald Trump has responded to his federal indictment the way he has responded to various other crises – with a blizzard of dishonesty. Here is a fact check of 10 of the indictment-related claims Trump has made since the 37 federal charges against him were unsealed on Friday. Trump and the Presidential Records ActTrump claimed in North Carolina that he had abided by the Presidential Records Act: “And we had a great – we had a wonderful operation, everything by the Presidential Records Act.”Facts First: This is false. The Presidential Records Act says that all presidential records belong to the federal government the moment the president leaves office. Margaret Kwoka, a law professor at The Ohio State University and an expert on information law, said in a Friday email that “any comparison between congressional records and presidential records is an apples-to-oranges comparison.
Persons: Donald Trump, Trump, Joe Biden’s, , , Walt Nauta, HUNT, , Everybody, ‘ We’ve, , it’s, Brandon Van Grack, Mueller, Harold Martin “, Lago, Ronald Reagan’s, didn’t, ” Jason R, baselessly musing, , Justice Department “, Trump’s, Biden, Joe Biden, Jack Smith, Smith, General Merrick Garland, Garland, ” Trump, CNN’s Paula Reid, Margaret Kwoka, “ He’s, Biden “, “ he’s, ” Biden Organizations: Washington CNN, Records, FBI, Trump, Trump In, Justice Department, National Security Agency, National Archives, Records Administration, NARA, Presidential Records, Presidential, Mar, White, New York Times, Biden, University of Delaware, The Ohio State University, Biden – Locations: Georgia, North Carolina, Mar, Lago, United States, Florida, Delaware, Washington
Creating a penis from a vagina is more complicated than turning a penis into a vagina. Then, they must define their priorities for their penis, Horwitz said. Then, during a meta, doctors cut ligaments around the newly enlarged clitoris, allowing it to extend away from the body. Phalloplasty creates a penis from a skin graftScar left over from a skin graft taken for a phalloplasty surgery. Once they've formed the neo-phallus (new penis), doctors surgically connect it to the genitals' nerve and vascular system.
They found that networking can make some people feel morally impure and dirtier afterwards. She and coauthors explored where that feeling comes from and found that networking can make people feel morally impure. After all, junior professionals often stand to gain the most from networking, so they're doing themselves no favors if they're networking-averse. "They don't feel like they're taking advantage of their networking partner, which makes them come across as more authentic." The reason may come down to the types of information that men versus women need to succeed.
Opioids contributed to 80,411 overdose deaths in 2021, up from 68,630 deaths in 2020, data from the National Institute on Drug Abuse shows. Xylazine is a sedative that can lead to respiratory and cardiac issuesOpioids, like fentanyl, contributed to more than 80,000 overdose deaths in 2021. Mixing xylazine with fentanyl is particularly problematicMixing xylazine and fentanyl can amplify xylazine's sedative effect and the associated health risks. ReutersThe opioid overdose reversal drug Narcan, also known as naloxone, will not reverse the impact of xylazine, since the drug is not an opioid, according to the DEA. That's because opioids account for nearly 75% of all drug overdose deaths in the US.
New York CNN —For decades, Girl Scouts has used cookie sales to raise funds and teach scouts about entrepreneurship. “Right now we are focused on ensuring all Girl Scouts have a successful Cookie Season,” Girl Scouts USA told CNN in a statement, adding that it is also focused on optimizing its operations “in real-time, and [capturing] learnings that will inform our strategy going into future seasons.”But for the scouts, those learnings have been hard-won. That meant shoppers could order it themselves, though Girl Scouts encouraged them to ask scouts to place the orders. Plus, Girl Scouts built a lot of hype with the limited-time offer, creating a sense of urgency, Esper noted. Francine Orr/Los Angeles Times/Getty ImagesYet as customers clamored for the cookie, scouts and their parents learned there was no chance of increasing supply by the end of the cookie season in April.
If the first Cold War was defined by the development of nuclear weapons, this Tech Cold War is defined by the computer chip. The massive Intel plant in Ohio is a key part of the race with China for the future of tech. Even before the Intel plant, the Columbus area was well acquainted with these sorts of trade-offs. But, the Ohio State study found, Columbus' residential tax-abatement programs did little to meaningfully address the housing problem, while draining the city's funds. Federal, state, and local subsidies add up to billions of dollars that Intel is saving on its new Ohio semiconductor factory.
Phood allows students to order DoorDash using their university dining dollars. The startup works with university campuses to let students spend their dining dollars on off-campus food purchases such as delivery through DoorDash, founder Alex Parmley told Insider. Parmley said that he sees opportunities to open up college students' dining dollars to lots of off-campus services and retailers. At first, the New York-based startup provided food delivery itself, using a team of couriers to send dining-hall food to students' dorm rooms and apartments. The company now connects students' dining accounts to the Discover Global Network, which allows them to use their dining dollars like a regular debit card outside of their university.
Fans of Megan Thee Stallion are trying to shift the public’s attention away from what they believe to be a misogynistic narrative around the current trial against Tory Lanez, who is accused of shooting the rapper in the foot. Digital alchemy is the practice of Black women and women of color using the internet to combat and counter misogynoir. “Especially for Black women, violence against women in our community is very common.”She noticed that online a lot of fans are calling out people who are highlighting Pete’s sexual history. “People have called it the Meg and Tory trial when she’s not on trial for anything,” Lindsey, who is author of “America Goddam: Violence, Black Women, and The Struggle for Justice,” said. “When people talk about Megan Thee Stallion getting shot, all the headlines are Megan Thee Stallion is on trial and I’m not on trial!”Hernandez said supporters recognize that slut shaming is being used to discredit Pete and paint her as an imperfect victim.
Suicide prevention: Signs, risk factors and how to help
  + stars: | 2022-12-14 | by ( Kristen Rogers | ) edition.cnn.com   time to read: +11 min
CNN —Suicide is a leading cause of death among children and adults, but spotting risk factors and warning signs isn’t easy. Here are some of the most common behavioral, verbal and emotional signs and risk factors you should pay attention to, according to experts. Mood and other risk factorsPsychological factors, distressing situations or genetics can increase the likelihood of someone considering, attempting or dying by suicide, according to SAMHSA. These risk factors can’t cause or predict a suicide attempt, but being aware of them is important, according to SAMHSA:Hopelessness. “You’re not going to cause someone to be suicidal by asking directly about suicide,” Baker said.
The first-of-its-kind study was presented Thursday at the San Antonio Breast Cancer Symposium, an annual meeting of breast cancer specialists. Faced with this possibility, Partridge said, many women stop or never start endocrine therapy, against the advice of their doctors. The findings were highly anticipated by other breast cancer specialists. Women in her practice were already making the executive decision to stop endocrine therapy for the chance of having a baby. Johnson was diagnosed with stage 2 breast cancer at age 34.
This first-of-its-kind dashboard was developed to track nonfatal opioid overdoses, which have become a growing public health concern as the US struggles with a decades-long opioid epidemic. It will “empower local communities” to tailor their opioid overdose responses and track their progress, Gupta said. “We know that there are significantly more nonfatal overdoses than fatal ones, of which there are over 100,000 a year. Across the United States, the powerful synthetic opioid fentanyl has become the most commonly used drug involved in drug overdoses. In 2020, a report from the CDC found that opioids have “substantial involvement” in nonfatal overdoses, including those involving other types of drugs, and these types of nonfatal overdoses are on the rise.
CNN —A measles outbreak in central Ohio is growing, sickening more than 50 children, with many of them needing hospitalization, according to data updated Tuesday by Columbus Public Health. “Measles can be very serious, especially for children under age 5,” Columbus Public Health spokesperson Kelli Newman wrote in an email Monday. In the Ohio outbreak, the hospitalized children have been seen at Nationwide Children’s Hospital. “For measles, it is the most infectious disease we have,” she said. Pediatric hospitals already strainedWhile the measles outbreak spreads across central Ohio, the United States has been battling a surge of respiratory illnesses, such as flu and RSV, or respiratory syncytial virus, and the ongoing Covid-19 pandemic.
Amazon Launches Supply-Chain Software Service
  + stars: | 2022-11-29 | by ( Paul Berger | ) www.wsj.com   time to read: +2 min
Amazon’s launch of its cloud application, AWS Supply Chain, adds Amazon to a growing list of software suppliers, such as Manhattan Associates and Blue Yonder, that help merchants juggle increasingly complex cargo flows and inventory demands. Microsoft Corp. launched its own supply-chain management software platform earlier this month. Companies are relying more on sophisticated supply-chain software as a growing share of sales shifts away from sending goods in bulk to retailers and moves more toward direct-to-consumer online sales that require better balancing and positioning of stock. Amazon has a ready audience for its software with a phalanx of small- and medium-size businesses in its third-party marketplace. The software identifies risks and provides recommendations to guard against shortages and delays so that companies can “quickly see and respond to potential supply-chain disruptions,” said Diego Pantoja-Navajas, vice president of AWS Supply Chain at Amazon Web Services.
Photo: Sarah Oden/Associated PressWomen and people of color are being hired into top roles in the logistics industry. United Parcel Service Inc. turned to Carol Tomé, a former finance chief at Home Depot Inc., in 2020 to become chief executive officer. Raj Subramaniam, who is from India, was chosen to succeed FedEx Corp. founder Fred Smith as chief executive earlier this year. Judy McReynolds has been chief executive of ArcBest Corp. , one of the largest trucking companies in the U.S., since 2010. Studies also show there is a big gap in pay across the logistics industry.
Social media users are sharing a claim that President Joe Biden “announced” a plan to cheat on the U.S. midterms by dumping ballots in a Nov. 2, 2022 speech. But nowhere in the speech does Biden “announce” cheating or dumping ballots during the midterm elections. Specifically, mail-in ballots can start being counted ranging from before election day, on election day before polls close and after polls close on election day, depending on the state (here). Reuters has previously reported on why official U.S. election vote counts may not be reported until after election day and can take weeks to verify (here). There are multiple layers of security in place for mail-in ballots, from affidavits and signature verification to witness signatures and notarized ballots.
Retailers this holiday season are focusing on delivering packages to customers on specific dates, rather than competing on speed of delivery. With inflation-conscious consumers now dialing back their online shopping, many retailers are focused on restraining the high costs of fulfillment and last-mile delivery. In 2019, the e-commerce giant also gave its Prime members the option to pick a specific delivery date. The feature refines the retailer’s previous three- to five-day shipping window, said Shivi Shankaran, the company’s chief operating officer. “Sometimes they want it really, really fast, or they want it really, really scheduled,” Mr. Gorlin said.
Israel-based robotics startup Get Fabric Ltd., which has placed so-called microfulfillment centers in New York City and Dallas, is focusing on selling its warehouse automation platform rather than building more specialized small distribution sites. Some companies leased vacant retail spaces for use as “dark stores” for fulfillment and delivery, while others opened smaller warehouses near population centers. The shift makes the niche logistics business the latest to see a business strategy that gained traction during the Covid-19 pandemic lose its momentum as consumers have resumed prepandemic buying habits. That has some retailers rethinking their heavy investments in online fulfillment. Takeoff Technologies Inc., a microfulfillment system provider, expanded its business in the past year, said co-founder and Chief Executive Max Pedró.
Ford Motor Co.’s moves to overhaul its supply-chain leadership reflect the increasingly crucial role technology is playing as the development of electric vehicles is transforming the way cars are produced. Ford said the company is seeking to align operations from sourcing and assembly to distribution with a goal of transitioning to EVs. Ford also plans to name its first chief supply-chain officer. It had sold more than 36,500 electric vehicles year-to-date through August. Ford has been working on building closer ties with its suppliers for years, but pandemic-related supply-chain snarls have made it a more urgent priority, the company spokesman said.
The Parental Burnout Test
  + stars: | 2022-06-06 | by ( Catherine Pearson | ) www.nytimes.com   time to read: +1 min
The past two-plus years have been relentless for working parents, who have frequently been placed in the impossible position of doing their jobs and parenting simultaneously. And a recent survey, by researchers with Ohio State University, suggests they have paid a steep emotional price. In 2021, 66 percent of working parents met the criteria for parental burnout — a nonclinical term that basically means they were so physically and mentally depleted that they may feel like bad parents or emotionally pull away from their children. The researchers based their findings on an online survey of 1,285 working parents who responded to their 10-question “Working Parent Burnout Scale.” The test is a tool that moms and dads can use to assess whether their burnout goes beyond the fatigue that all parents feel at some point — and just how serious it is. “It’s this constant feeling of having to be on, 24/7,” said Kate Gawlik, an associate professor of clinical nursing at the Ohio State University College of Nursing and a co-author of the report.
Robert and Rebekah Mercer ranked among President Donald Trump's most influential backers in 2016. A representative for Priorities USA Action, a leading pro-Biden super PAC, said the organization wasn't underestimating Trump's reelection forces, Mercers or no Mercers. (Bossie, like former Trump campaign manager Corey Lewandowski and many others, has recently found himself back in Trump's favor.) The Cambridge Analytica data that the Trump campaign paid for was "so stupidly wrong" and a "complete joke," Spicer added. But sources familiar with the Mercers' political spending said they have no evidence that the Mercers are doing so.
Cancer on the rise, and HPV vaccine too late for Gen X
  + stars: | 2015-11-05 | by ( Martha Shade | ) edition.cnn.com   time to read: +6 min
Evidence is mounting that the HPV vaccine is also effective in preventing other HPV-related cancers, including those of the head and neck. When Gillison recently gave a presentation showing the increasing rate of HPV-related head and neck cancer among men, her audience was shocked. It can lay dormant, and most oropharyngeal cancer (a type of head and neck cancer) is diagnosed decades later, beginning around age 40 to 50. This is one more thing to add to that list that you really have to watch for,” said Brian Hill, founder of the Oral Cancer Foundation. When it’s diagnosed early, these HPV-related cancers are survivable, according to Dr. Carole Fakhry of the Johns Hopkins Head & Neck Cancer Center.
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